Trimethoprim-sulfamethoxazole (TMP-SMX, generic for Bactrim, and also abbreviated SMZ-TMP) is an antibiotic. It may be used to treat urinary tract or ear infections in pediatric patients. Other antibiotics are usually preferred as first-line treatment options. The suspension form of this medication contains sulfamethoxazole (SMX) 200 mg and trimethoprim (TMP) 40 mg together in each 5 mL liquid. Dosing is based on the trimethoprim (TMP) component.
Do not use if there is a history of allergy or hypersensitivity to sulfa drugs or TMP-SMX. Do not use with a history of liver or kidney disease. Do not use in patients less than 2 months of age.
Avoid if allergic to sulfa drugs. TMP-SMX can cause rare but fatal reactions including life-threatening types of rash (Stevens-Johnson syndrome, toxic epidermal necrolysis), liver failure (fulminant hepatic necrosis), and life-threatening low blood counts (aplastic anemia and thrombocytopenia). TMP-SMX can cause severe diarrhea (including C. difficile diarrhea). Stop taking TMP-SMX at the first sign of any rash.
|Infection (pediatric)||TMP-SMX pediatric 4 mg TMP per kg by mouth every 12 hours for 7 days. Maximum 160 mg TMP per dose.|
Pediatric dosages are weight-based. Refer to weight-based dosing guidelines.
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