Atovaquone-proguanil (generic for Malarone) is used for malaria prophylaxis in areas with chloroquine-resistant Plasmodium falciparum, and can be used in most parts of the world where malaria occurs. Take it daily for 1-2 days before possible exposure to malaria, and continue daily for 7 days after leaving an exposed area. If you plan to travel to malaria-endemic areas, discuss with your Duration Health provider to determine which prophylaxis is appropriate for you.
Absorption of atovaquone may be reduced in patients with diarrhea or vomiting, so the medication may not work as well. Relapse of malaria may occur if atovaquone-proguanil is used when someone is infected with multiple species of malaria parasite.
Do not use this or any other oral medication to treat severe malaria, because patients who are severely ill with malaria must be treated with IV medications. This medication can cause liver failure, and some people have needed a liver transplant after using this medication prophylactically for prevention of malaria. Atovaquone-proguanil tablets are contraindicated in individuals with known hypersensitivity reactions or allergic reaction to the medication or any of its components. Atovaquone-proguanil tablets are contraindicated for prophylaxis of P. falciparum malaria in patients with severe renal impairment.
|Malaria prophylaxis||250 mg atovaquone and 100 mg proguanil hydrochloride, 1 tablet by mouth once daily, begin 1–2 days before travel to malarious areas, take daily at the same time each day while in the malarious area, and for 7 days after leaving such areas|
Adult doses are shown, unless otherwise specified. Refer to weight-based dosing guidelines for pediatric patients.
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